Hi! Welcome aboard (yes, some of the Gods are still watching the mortals

)
Don't forget to come and say hello in the "Introductions" thread in the Off-Topic section of the Forum - right at the bottom of the page.
The Runes will test your anagram skills to the limit as you progress - several people have used a set of Scrabble tiles to help them. The Knots are simply the most obvious example of this..
And think of the letters in the Labyrinths as being different possible exits from the maze. All you have to do is find which of the exits (i.e. which letter) is the "right" one.
The only comment I will make from the start is that you should never give up. There will be times in this puzzle when you want to burn it, throw it away, tear it up, kill the Gatekeeper - we've all been there! But there are lots of us now that prove that it's all possible.